HGH 12IU

Human Growth Hormone (HGH) 12IU is a recombinant somatropin preparation containing 4mg of lyophilized HGH per vial — chemically and structurally identical to endogenous pituitary hGH (191 amino acids, 22 kDa). Each vial provides 12 international units for laboratory research applications.

Molecular Characteristics & Mechanism of Action
HGH exerts its biological effects through sequential binding to two GHR monomers, inducing receptor dimerization that activates Janus kinase 2 (JAK2). Activated JAK2 phosphorylates tyrosine residues on the GHR cytoplasmic domain, creating docking sites for STAT5 and downstream effectors including MAPK/ERK and PI3K/Akt pathways. STAT5 translocation to the nucleus drives transcription of IGF-1 and other GH-responsive genes. In adipose tissue, GH directly stimulates hormone-sensitive lipase activity, promoting triglyceride hydrolysis and free fatty acid release.

Research Applications
HGH 12IU is ideal for pilot studies and dose-response experiments investigating somatotropin receptor signaling, IGF-1 axis regulation, cellular proliferation pathways, and the metabolic consequences of GH-IGF-1 signaling across in vitro and in vivo models. The 12IU format provides a convenient quantity for preliminary experiments before scaling to larger protocols.

Storage & Handling
Lyophilized HGH should be stored at 2-8°C. After reconstitution with bacteriostatic water (not included), store at 2-8°C and use within 14-21 days. Do not shake vigorously — swirl gently to reconstitute. Avoid repeated freeze-thaw cycles.

Quality Control
BioSim Peptides HGH 12IU is purified to 98%+ as verified by SDS-PAGE, HPLC, and mass spectrometry. Each batch includes a certificate of analysis. Manufactured in USA facilities.

For research use only. Not for human consumption.