SS-31 (Sulfur Substituted Peptide) – 50mg

SS-31 is a modified peptide variant derived from the original SS-1 (sulfur-substituted collagen peptide), designed for targeted research applications in biological and biochemical studies. This peptide structure incorporates additional sulfur-containing modifications, enhancing its stability and specificity in cellular and extracellular matrix experiments. Below is detailed information regarding its development, research applications, and context within molecular biology.

Research Context

SS-31 was first introduced as a potent inhibitor of extracellular matrix proteins, including collagen, elastin, and fibronectin. Its sulfur substitution enhances its resistance to proteolytic degradation while retaining high affinity for these components. Research utilizing SS-31 has primarily focused on understanding the biochemical mechanisms underlying matrix remodeling, fibrotic diseases, and tissue repair processes.

Research Overview

SS-31’s structural modifications provide a significant advantage over native peptides by improving its ability to penetrate cellular membranes and resist enzymatic cleavage. Early studies demonstrated its utility in modulating inflammatory responses, reducing fibrosis in animal models, and exploring its potential role in neurodegenerative research. Due to its modified amino acid composition, SS-31 may also be valuable in studying protein-protein interactions within the extracellular matrix.

Key Research Focus Areas

• Matrix Remodeling and Fibrosis: Investigating the role of SS-31 in inhibiting collagen and elastin deposition, particularly in models of pulmonary fibrosis, cardiac remodeling, and skin fibrosis.
• Neurodegenerative Diseases: Exploring its potential neuroprotective effects by modulating extracellular matrix interactions in models of Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury.
• Inflammation and Immune Response: Assessing its impact on inflammatory pathways, particularly in contexts where matrix degradation contributes to chronic inflammation.
• Tissue Engineering: Utilizing SS-31 to enhance biocompatibility and scaffold stability in regenerative medicine applications.
• Pharmacological Screening: Employing SS-31 as a probe to characterize interactions between matrix proteins and cellular receptors.

Researchers using SS-31 must ensure proper handling, storage, and validation protocols are adhered to, as its modified structure may introduce unique stability and reactivity considerations.

Safety and Compliance Considerations

Due to its peptide nature, SS-31 exhibits potential for immunogenicity and enzymatic degradation, requiring careful experimental design to mitigate risks. Researchers should conduct preliminary studies to assess its specificity, stability, and potential off-target effects within their experimental models. Always consult with academic or institutional safety committees prior to use.

For research use only. Not for human or animal consumption.